MolNFT v1 · #60396 · protein
Nucleoporin NUP107/NUP133 interaction complex, delta finger mutant
3CQG · Nuclear pore complex protein NUP107: “Nucleoporin NUP107/NUP133 interaction complex, delta finger mutant”. X-ray diffraction, 3 pockets (best druggability 0.63). MolNFT v1 #60396 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 3CQG
- Type
- protein
- Length
- 409 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear pore complex protein NUP107; Nuclear pore complex protein NUP133
- UniProt
- P57740, Q8WUM0
- Pockets
- 3 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear pore complex protein NUP107 | protein | 225 | 72% helix, 0% strand | P57740 |
| B | Nuclear pore complex protein NUP133 | protein | 184 | 70% helix, 0% strand | Q8WUM0 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 292 | 0.63 | 0.80 | 32 | empty |
| 2 | 209 | 0.53 | 0.77 | 30 | empty |
| 3 | 100 | 0.40 | 0.77 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1234 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 3CQG · Nucleoporin Nup107/Nup133 interaction complex, delta finger mutant · the same entry in another collection · chain A against A, TM-score 1.00
- Q8WUM0 · AlphaFold monomer V2.0 prediction for nuclear pore complex protein NUP133 (Q8WUM0) · a predicted model of the same protein · chain B against A, TM-score 0.96
- P57740 · AlphaFold monomer V2.0 prediction for nuclear pore complex protein NUP107 (P57740) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P57740
- Every structure of UniProt Q8WUM0
- Elsewhere: RCSB PDB 3CQG · PDBe 3CQG · UniProt P57740 · UniProt Q8WUM0
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