MolNFT v1 · #60298 · protein

Cholesterol oxidase from streptomyces sp. F359W mutant (0.95A)

3CNJ: “Cholesterol oxidase from streptomyces sp. F359W mutant (0.95A)”. X-ray diffraction, 2 ligands (FAD, SO4), 4 pockets (best druggability 0.87). MolNFT v1 #60298 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3CNJ
Type: protein
Length: 499 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cholesterol oxidase
EC: 1.1.3.6
UniProt: P12676
Ligands: FAD, SO4
Pockets: 4 · best druggability 0.87

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cholesterol oxidase (EC 1.1.3.6)	protein	499	29% helix, 23% strand	P12676

Ligands and binding sites

FAD · Flavin-adenine dinucleotide · ligand · chains A
SO4 · Sulfate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	701	0.87	0.90	89	FAD
2	127	0.41	0.75	22	empty
3	71	0.36	0.77	22	empty
4	63	0.29	0.74	18	empty

Compared structures

3CNJ · Cholesterol oxidase from Streptomyces sp. F359W mutant (0.95A) · the same entry in another collection · chain A against A, TM-score 1.00
P12676 · AlphaFold monomer V2.0 prediction for cholesterol oxidase (P12676) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P12676
Elsewhere: RCSB PDB 3CNJ · PDBe 3CNJ · UniProt P12676

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.