MolNFT v1 · #59219 · protein + DNA
Csl (lag-1) bound to DNA with lin-12 ram peptide, C2221
3BRF · DNA (5'- D(*DTP*DTP*DAP*DCP*DTP*DGP*DTP*DGP*DGP*DGP*DAP*DAP*…: “Csl (lag-1) bound to DNA with lin-12 ram peptide, C2221”. X-ray diffraction, 1 ligand (SOR), 7 pockets (best druggability 0.68). MolNFT v1 #59219 on GenesisL1: 3D…
- PDB
- 3BRF
- Type
- protein + DNA
- Length
- 466 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'- D(*DTP*DTP*DAP*DCP*DTP*DGP*DTP*DGP*DGP*DGP*DAP*DAP*DAP*DGP*DA)-3'); DNA (5'…
- UniProt
- Q9TYY1, P14585
- Ligands
- SOR
- Pockets
- 7 · best druggability 0.68
Structure
x-ray diffraction · 4 distinct chains · 9% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | DNA (5'- D(*DTP*DTP*DAP*DCP*DTP*DGP*DTP*DGP*DGP*DGP*DAP*DAP*DAP*DGP*DA)-3') | dna | 15 | — | — |
| C | DNA (5'- D(*DAP*DAP*DTP*DCP*DTP*DTP*DTP*DCP*DCP*DCP*DAP*DCP*DAP*DGP*DT)-3') | dna | 15 | — | — |
| A | Lin-12 and glp-1 phenotype protein 1, isoform a | protein | 423 | 9% helix, 45% strand | Q9TYY1 |
| D | Protein lin-12 | protein | 13 | 0% helix, 31% strand | P14585 |
Ligands and binding sites
- SOR · sorbitol · ligand · 2 copies · chains C, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 269 | 0.68 | 0.84 | 36 | empty |
| 2 | 192 | 0.54 | 0.79 | 21 | empty |
| 3 | 137 | 0.49 | 0.79 | 22 | empty |
| 4 | 170 | 0.47 | 0.76 | 21 | empty |
| 5 | 161 | 0.46 | 0.76 | 30 | SOR |
Interfaces
4 interfaces between chains.
- A–D · 952 Ų buried · 15 hydrogen bonds · protein-protein
- C–A · 627 Ų buried · 13 hydrogen bonds · protein-nucleic
- B–A · 620 Ų buried · 11 hydrogen bonds · protein-nucleic
- B–C · 585 Ų buried · 62 hydrogen bonds · nucleic-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9TYY1
- Every structure of UniProt P14585
- Elsewhere: RCSB PDB 3BRF · PDBe 3BRF · UniProt Q9TYY1 · UniProt P14585
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.