MolNFT v1 · #58546 · protein
CD4 endocytosis motif bound to the focal adhesion targeting (fat) domain of the focal adhesion kinase
3B71 · Focal adhesion kinase 1: “CD4 endocytosis motif bound to the focal adhesion targeting (fat) domain of the focal adhesion kinase”. X-ray diffraction, 7 pockets (best druggability 0.42). MolNFT v1 #58546 on GenesisL1: 3D structure…
- PDB
- 3B71
- Type
- protein
- Length
- 443 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Focal adhesion kinase 1; T-cell surface glycoprotein CD4
- EC
- 2.7.10.2
- UniProt
- Q05397, P01730
- Pockets
- 7 · best druggability 0.42
Structure
x-ray diffraction · 4 distinct chains · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Focal adhesion kinase 1 (EC 2.7.10.2) | protein | 134 | 83% helix, 0% strand | Q05397 |
| B, C | Focal adhesion kinase 1 (EC 2.7.10.2) | protein | 139 | 80% helix, 0% strand | Q05397 |
| D, E | T-cell surface glycoprotein CD4 | protein | 11 | 64% helix, 0% strand | P01730 |
| F | T-cell surface glycoprotein CD4 | protein | 9 | 44% helix, 0% strand | P01730 |
Pockets
7 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 54 | 0.42 | 0.82 | 17 | empty |
| 2 | 79 | 0.42 | 0.80 | 22 | empty |
| 3 | 111 | 0.42 | 0.77 | 22 | empty |
| 4 | 93 | 0.37 | 0.75 | 19 | empty |
| 5 | 106 | 0.36 | 0.74 | 23 | empty |
Interfaces
6 interfaces between chains.
- A–B · 715 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 704 Ų buried · 6 hydrogen bonds · protein-protein
- B–E · 506 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 449 Ų buried · 2 hydrogen bonds · protein-protein
- C–F · 424 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 3B71 · CD4 endocytosis motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal… · the same entry in another collection · chain F against F, TM-score 1.00
- Q05397 · AlphaFold monomer V2.0 prediction for focal adhesion kinase 1 (Q05397) · a predicted model of the same protein · chain A against A, TM-score 0.95
- P01730 · AlphaFold monomer V2.0 prediction for T-cell surface glycoprotein CD4 (P01730) · a predicted model of the same protein · chain F against A, TM-score 0.63
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q05397
- Every structure of UniProt P01730
- Elsewhere: RCSB PDB 3B71 · PDBe 3B71 · UniProt Q05397 · UniProt P01730
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