Research workbench
CD4 endocytosis motif bound to the focal adhesion targeting (fat) domain of the focal adhesion kinase
Analyse CD4 endocytosis motif bound to the focal adhesion targeting (fat) domain of the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3B71
- Type
- protein
- Length
- 443 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Focal adhesion kinase 1; T-cell surface glycoprotein CD4
- EC
- 2.7.10.2
- UniProt
- Q05397, P01730
- Pockets
- 7 · best druggability 0.42
Structure
x-ray diffraction · 4 distinct chains · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Focal adhesion kinase 1 (EC 2.7.10.2) | protein | 134 | 83% helix, 0% strand | Q05397 |
| B, C | Focal adhesion kinase 1 (EC 2.7.10.2) | protein | 139 | 80% helix, 0% strand | Q05397 |
| D, E | T-cell surface glycoprotein CD4 | protein | 11 | 64% helix, 0% strand | P01730 |
| F | T-cell surface glycoprotein CD4 | protein | 9 | 44% helix, 0% strand | P01730 |
Pockets
7 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 54 | 0.42 | 0.82 | 17 | empty |
| 2 | 79 | 0.42 | 0.80 | 22 | empty |
| 3 | 111 | 0.42 | 0.77 | 22 | empty |
| 4 | 93 | 0.37 | 0.75 | 19 | empty |
| 5 | 106 | 0.36 | 0.74 | 23 | empty |
Interfaces
6 interfaces between chains.
- A–B · 715 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 704 Ų buried · 6 hydrogen bonds · protein-protein
- B–E · 506 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 449 Ų buried · 2 hydrogen bonds · protein-protein
- C–F · 424 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 3B71 · CD4 endocytosis motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal… · the same entry in another collection · chain F against F, TM-score 1.00
- Q05397 · AlphaFold monomer V2.0 prediction for focal adhesion kinase 1 (Q05397) · a predicted model of the same protein · chain A against A, TM-score 0.95
- P01730 · AlphaFold monomer V2.0 prediction for T-cell surface glycoprotein CD4 (P01730) · a predicted model of the same protein · chain F against A, TM-score 0.63
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q05397
- Every structure of UniProt P01730
- Elsewhere: RCSB PDB 3B71 · PDBe 3B71 · UniProt Q05397 · UniProt P01730
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