MolNFT v1 · #57624 · protein + RNA
Structure of TRBP2 and its molecule implications for miRNA processing
3ADL · Risc-loading complex subunit TARBP2: “Structure of TRBP2 and its molecule implications for miRNA processing”. X-ray diffraction, 1 pocket (best druggability 0.43). MolNFT v1 #57624 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3ADL
- Type
- protein + RNA
- Length
- 96 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Risc-loading complex subunit TARBP2; RNA (5'-R(P*CP*GP*CP*GP*CP*GP*CP*GP*CP*G)-3')
- UniProt
- Q15633
- Pockets
- 1 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Risc-loading complex subunit TARBP2 | protein | 76 | 37% helix, 30% strand | Q15633 |
| B, C | RNA (5'-R(P*CP*GP*CP*GP*CP*GP*CP*GP*CP*G)-3') | rna | 10 | — | — |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 220 | 0.43 | 0.73 | 18 | empty |
Interfaces
3 interfaces between chains.
- B–C · 538 Ų buried · 65 hydrogen bonds · nucleic-nucleic
- A–C · 222 Ų buried · 3 hydrogen bonds · protein-nucleic
- A–B · 157 Ų buried · 2 hydrogen bonds · protein-nucleic
Compared structures
- 3ADL · Structure of TRBP2 and its molecule implications for miRNA processing · the same entry in another collection · chain A against A, TM-score 1.00
- Q15633 · AlphaFold monomer V2.0 prediction for risc-loading complex subunit TARBP2 (Q15633) · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15633
- Elsewhere: RCSB PDB 3ADL · PDBe 3ADL · UniProt Q15633
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