MolNFT v1 · #56616 · protein
Crystal structure of phospholipase C beta 2
2ZKM · 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase…: “Crystal structure of phospholipase C beta 2”. X-ray diffraction, 1 ligand (CA), 9 pockets (best druggability 0.76). MolNFT v1 #56616 on GenesisL1: 3D structure, binding…
- PDB
- 2ZKM
- Type
- protein
- Length
- 708 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2
- EC
- 3.1.4.11
- UniProt
- Q00722
- Ligands
- CA
- Pockets
- 9 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| X | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 (EC 3.1.4.11) | protein | 708 | 32% helix, 23% strand | Q00722 |
Ligands and binding sites
- CA · Calcium ion · metal · chains X
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 174 | 0.76 | 0.93 | 27 | empty |
| 2 | 184 | 0.72 | 0.89 | 26 | empty |
| 3 | 404 | 0.69 | 0.81 | 50 | empty |
| 4 | 227 | 0.58 | 0.79 | 34 | empty |
| 5 | 289 | 0.54 | 0.75 | 37 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00722
- Elsewhere: RCSB PDB 2ZKM · PDBe 2ZKM · UniProt Q00722
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.