UniProt Q00722
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (Q00722)
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (UniProt Q00722), EC 3.1.4.11: 4 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 49 pockets. Binding sites, druggability and experiment…
- UniProt
- Q00722
- Protein
- 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2
- EC
- 3.1.4.11
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 49 · 5 records with a druggable one
Structures
5 records of Q00722 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2FJU | Activated Rac1 bound to its effector phospholipase C beta 2 | x-ray diffraction | B | CA | 10 (best 0.77) |
| 2FJU | Activated RAC1 bound to its effector phospholipase C beta 2 | x-ray diffraction | B | CA | 10 (best 0.77) |
| 2ZKM | Crystal Structure of Phospholipase C Beta 2 | x-ray diffraction | X | CA | 9 (best 0.76) |
| 2ZKM | Crystal structure of phospholipase C beta 2 | x-ray diffraction | X | CA | 9 (best 0.76) |
| Q00722 | AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase… | predicted | A | — | 11 (best 0.79) |
Ligands
- CA · Calcium ion · in 4 records
Experiment against prediction
- 2ZKM chain X against the predicted model Q00722: TM-score 1.00, RMSD 0.65 Å
- 2ZKM chain X against the predicted model Q00722: TM-score 1.00, RMSD 0.65 Å
- 2FJU chain B against the predicted model Q00722: TM-score 0.99, RMSD 1.11 Å
- 2FJU chain B against the predicted model Q00722: TM-score 0.99, RMSD 1.11 Å
Elsewhere
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