MolNFT v1 · #56438 · protein
The crystal structure of plant specific calcium binding protein ATCBL2 in complex with the regulatory domain of ATCIPK14
2ZFD · Calcineurin B-like protein 2: “The crystal structure of plant specific calcium binding protein ATCBL2 in complex with the regulatory domain…”. X-ray diffraction, 1 ligand (CA), 3 pockets (best druggability 0.52). MolNFT v1 #56438 on…
- PDB
- 2ZFD
- Type
- protein
- Length
- 299 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcineurin B-like protein 2; Putative uncharacterized protein T20L15_90
- UniProt
- Q8LAS7, Q9LZW4
- Ligands
- CA
- Pockets
- 3 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 53% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calcineurin B-like protein 2 | protein | 183 | 64% helix, 3% strand | Q8LAS7 |
| B | Putative uncharacterized protein T20L15_90 | protein | 116 | 36% helix, 31% strand | Q9LZW4 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 199 | 0.52 | 0.78 | 22 | empty |
| 2 | 70 | 0.34 | 0.76 | 16 | empty |
| 3 | 76 | 0.31 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1640 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 2ZFD · The crystal structure of plant specific calcium binding protein AtCBL2 in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8LAS7 · AlphaFold monomer V2.0 prediction for calcineurin B-like protein 2 (Q8LAS7) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q9LZW4 · AlphaFold monomer V2.0 prediction for cbl-interacting SERINE/THREONINE-protein kinase 14… · a predicted model of the same protein · chain B against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8LAS7
- Every structure of UniProt Q9LZW4
- Elsewhere: RCSB PDB 2ZFD · PDBe 2ZFD · UniProt Q8LAS7 · UniProt Q9LZW4
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