MolNFT v1 · #56305 · protein

Crystal structure of mouse 15-ketoprostaglandin delta-13- reductase in complex with NADPH

2ZB3 · Prostaglandin reductase 2: “Crystal structure of mouse 15-ketoprostaglandin delta-13- reductase in complex with NADPH”. X-ray diffraction, 1 ligand (NDP), 2 pockets (best druggability 0.81). MolNFT v1 #56305 on GenesisL1: 3D…

PDB: 2ZB3
Type: protein
Length: 345 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Prostaglandin reductase 2
EC: 1.3.1.48
UniProt: Q8VDQ1
Ligands: NDP
Pockets: 2 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Prostaglandin reductase 2 (EC 1.3.1.48)	protein	345	35% helix, 28% strand	Q8VDQ1

Ligands and binding sites

NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	651	0.81	0.86	67	NDP
2	297	0.59	0.77	32	empty

Compared structures

2ZB3 · Crystal structure of mouse 15-ketoprostaglandin delta-13-reductase in complex with NADPH · the same entry in another collection · chain A against A, TM-score 1.00
Q8VDQ1 · AlphaFold monomer V2.0 prediction for prostaglandin reductase 2 (Q8VDQ1) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8VDQ1
Elsewhere: RCSB PDB 2ZB3 · PDBe 2ZB3 · UniProt Q8VDQ1

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