MolNFT v1 · #54419 · protein
Human annexin V with incorporated methionine analogue azidohomoalanine
2XO2 · Annexin A5: “Human annexin V with incorporated methionine analogue azidohomoalanine”. X-ray diffraction, 4 ligands (CA, NA, SO4), 4 pockets (best druggability 0.39). MolNFT v1 #54419 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2XO2
- Type
- protein
- Length
- 317 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Annexin A5
- UniProt
- P08758
- Ligands
- CA, NA, SO4, CL
- Pockets
- 4 · best druggability 0.39
Structure
x-ray diffraction · 1 distinct chain · 65% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Annexin A5 | protein | 317 | 65% helix, 0% strand | P08758 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A
- NA · Sodium ion · metal · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains A
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 82 | 0.39 | 0.77 | 17 | empty |
| 2 | 58 | 0.37 | 0.79 | 17 | empty |
| 3 | 72 | 0.36 | 0.77 | 15 | empty |
| 4 | 62 | 0.34 | 0.77 | 16 | empty |
Modifications
Observed in the structure: 7 modified (nonstandard).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08758
- Elsewhere: RCSB PDB 2XO2 · PDBe 2XO2 · UniProt P08758
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