MolNFT v1 · #54394 · protein
Crystal structure of an engineered ferredoxin NADP reductase (fnr) from pisum sativum
2XNC · Ferredoxin--NADP reductase, leaf isozyme, chloroplastic: “Crystal structure of an engineered ferredoxin NADP reductase (fnr) from pisum sativum”. X-ray diffraction, 2 ligands (FAD, SO4), 8 pockets (best druggability 0.61). MolNFT v1…
- PDB
- 2XNC
- Type
- protein
- Length
- 575 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ferredoxin--NADP reductase, leaf isozyme, chloroplastic
- EC
- 1.18.1.2
- UniProt
- P10933
- Ligands
- FAD, SO4
- Pockets
- 8 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic (EC 1.18.1.2) | protein | 287 | 26% helix, 29% strand | P10933 |
| B | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic (EC 1.18.1.2) | protein | 288 | 25% helix, 30% strand | P10933 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 444 | 0.61 | 0.75 | 48 | empty |
| 2 | 175 | 0.53 | 0.79 | 23 | empty |
| 3 | 179 | 0.50 | 0.77 | 27 | empty |
| 4 | 164 | 0.49 | 0.77 | 28 | FAD |
| 5 | 139 | 0.45 | 0.76 | 26 | FAD |
Interfaces
1 interface between chains.
- A–B · 410 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 2XNC · Crystal structure of an engineered Ferredoxin NADP reductase (FNR) from Pisum sativum · the same entry in another collection · chain A against A, TM-score 1.00
- P10933 · AlphaFold monomer V2.0 prediction for ferredoxin--NADP reductase, leaf isozyme… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10933
- Elsewhere: RCSB PDB 2XNC · PDBe 2XNC · UniProt P10933
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