Research workbench
Crystal structure of an engineered ferredoxin NADP reductase (fnr) from pisum sativum
Analyse Crystal structure of an engineered ferredoxin NADP reductase (fnr) from pisum… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2XNC
- Type
- protein
- Length
- 575 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ferredoxin--NADP reductase, leaf isozyme, chloroplastic
- EC
- 1.18.1.2
- UniProt
- P10933
- Ligands
- FAD, SO4
- Pockets
- 8 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic (EC 1.18.1.2) | protein | 287 | 26% helix, 29% strand | P10933 |
| B | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic (EC 1.18.1.2) | protein | 288 | 25% helix, 30% strand | P10933 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
- SO4 · Sulfate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 444 | 0.61 | 0.75 | 48 | empty |
| 2 | 175 | 0.53 | 0.79 | 23 | empty |
| 3 | 179 | 0.50 | 0.77 | 27 | empty |
| 4 | 164 | 0.49 | 0.77 | 28 | FAD |
| 5 | 139 | 0.45 | 0.76 | 26 | FAD |
Interfaces
1 interface between chains.
- A–B · 410 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 2XNC · Crystal structure of an engineered Ferredoxin NADP reductase (FNR) from Pisum sativum · the same entry in another collection · chain A against A, TM-score 1.00
- P10933 · AlphaFold monomer V2.0 prediction for ferredoxin--NADP reductase, leaf isozyme… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10933
- Elsewhere: RCSB PDB 2XNC · PDBe 2XNC · UniProt P10933
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