MolNFT v1 · #53656 · protein
Crystal structure of IMPORTIN13 - rangtp complex
2X19 · GTP-binding nuclear protein GSP1/CNR1: “Crystal structure of IMPORTIN13 - rangtp complex”. X-ray diffraction, 2 ligands (GTP, MG), 10 pockets (best druggability 0.80). MolNFT v1 #53656 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2X19
- Type
- protein
- Length
- 1,078 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GTP-binding nuclear protein GSP1/CNR1; Importin-13
- UniProt
- P32835, O94829
- Ligands
- GTP, MG
- Pockets
- 10 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 68% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GTP-binding nuclear protein GSP1/CNR1 | protein | 172 | 28% helix, 28% strand | P32835 |
| B | Importin-13 | protein | 906 | 76% helix, 0% strand | O94829 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1064 | 0.80 | 0.82 | 96 | GTP, MG |
| 2 | 1124 | 0.76 | 0.78 | 100 | empty |
| 3 | 53 | 0.62 | 0.93 | 22 | empty |
| 4 | 223 | 0.48 | 0.74 | 28 | empty |
| 5 | 60 | 0.43 | 0.82 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1682 Ų buried · 22 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 22 modified (engineered).
Compared structures
- 2X19 · Crystal structure of Importin13 - RanGTP complex · the same entry in another collection · chain A against A, TM-score 1.00
- O94829 · AlphaFold monomer V2.0 prediction for importin-13 (O94829) · a predicted model of the same protein · chain B against A, TM-score 0.97
- P32835 · AlphaFold monomer V2.0 prediction for GTP-binding nuclear protein GSP1/CNR1 (P32835) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32835
- Every structure of UniProt O94829
- Elsewhere: RCSB PDB 2X19 · PDBe 2X19 · UniProt P32835 · UniProt O94829
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