MolNFT v1 · #52450 · protein
Crystal structure of the C-terminal WD40 domain of human PALB2
2W18 · Partner and localizer of BRCA2: “Crystal structure of the C-terminal WD40 domain of human PALB2”. X-ray diffraction, 2 pockets (best druggability 0.74). MolNFT v1 #52450 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2W18
- Type
- protein
- Length
- 306 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Partner and localizer of BRCA2
- UniProt
- Q86YC2
- Pockets
- 2 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 0% helix, 60% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Partner and localizer of BRCA2 | protein | 306 | 0% helix, 60% strand | Q86YC2 |
Ligands and binding sites
- GOL · Glycerol · additive · 5 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 824 | 0.74 | 0.78 | 61 | GOL |
| 2 | 55 | 0.39 | 0.80 | 18 | GOL |
Compared structures
- 2W18 · Crystal structure of the C-terminal WD40 domain of human PALB2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q86YC2 · AlphaFold monomer V2.0 prediction for partner and localizer of BRCA2 (Q86YC2) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86YC2
- Elsewhere: RCSB PDB 2W18 · PDBe 2W18 · UniProt Q86YC2
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