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Crystal structure of the C-terminal WD40 domain of human PALB2

Analyse Crystal structure of the C-terminal WD40 domain of human PALB2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2W18
Type: protein
Length: 306 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Partner and localizer of BRCA2
UniProt: Q86YC2
Pockets: 2 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 0% helix, 60% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Partner and localizer of BRCA2	protein	306	0% helix, 60% strand	Q86YC2

Ligands and binding sites

GOL · Glycerol · additive · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	824	0.74	0.78	61	GOL
2	55	0.39	0.80	18	GOL

Compared structures

2W18 · Crystal structure of the C-terminal WD40 domain of human PALB2 · the same entry in another collection · chain A against A, TM-score 1.00
Q86YC2 · AlphaFold monomer V2.0 prediction for partner and localizer of BRCA2 (Q86YC2) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q86YC2
Elsewhere: RCSB PDB 2W18 · PDBe 2W18 · UniProt Q86YC2

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