MolNFT v1 · #51863 · protein

Crystal structure form ultalente insulin microcrystals

2VK0 · Insulin a chain: “Crystal structure form ultalente insulin microcrystals”. X-ray diffraction, 2 ligands (MPB, ZN). MolNFT v1 #51863 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2VK0
Type: protein
Length: 97 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin a chain; Insulin B chain
UniProt: P01308
Ligands: MPB, ZN

Structure

x-ray diffraction · 3 distinct chains · 55% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Insulin a chain	protein	21	62% helix, 10% strand	P01308
B	Insulin B chain	protein	28	54% helix, 14% strand	P01308
D	Insulin B chain	protein	27	52% helix, 11% strand	P01308

Ligands and binding sites

MPB · 4-hydroxy-benzoic acid methyl ester · ligand · chains C, D
ZN · Zinc ion · metal · 4 copies · chains B, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

5 interfaces between chains.

A–B · 770 Å² buried · 13 hydrogen bonds · protein-protein
C–D · 698 Å² buried · 8 hydrogen bonds · protein-protein
B–D · 628 Å² buried · 9 hydrogen bonds · protein-protein
A–D · 68 Å² buried · 0 hydrogen bonds · protein-protein
B–C · 52 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

2VK0 · Crystal structure form ultalente insulin microcrystals · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01308
Elsewhere: RCSB PDB 2VK0 · PDBe 2VK0 · UniProt P01308

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