Research workbench
Crystal structure form ultalente insulin microcrystals
Analyse Crystal structure form ultalente insulin microcrystals in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2VK0
- Type
- protein
- Length
- 97 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin a chain; Insulin B chain
- UniProt
- P01308
- Ligands
- MPB, ZN
Structure
x-ray diffraction · 3 distinct chains · 55% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Insulin a chain | protein | 21 | 62% helix, 10% strand | P01308 |
| B | Insulin B chain | protein | 28 | 54% helix, 14% strand | P01308 |
| D | Insulin B chain | protein | 27 | 52% helix, 11% strand | P01308 |
Ligands and binding sites
- MPB · 4-hydroxy-benzoic acid methyl ester · ligand · chains C, D
- ZN · Zinc ion · metal · 4 copies · chains B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
5 interfaces between chains.
- A–B · 770 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 698 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 628 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 68 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 52 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 2VK0 · Crystal structure form ultalente insulin microcrystals · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 2VK0 · PDBe 2VK0 · UniProt P01308
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