MolNFT v1 · #51009 · protein
Crystal structure of the rat FGF1-sucrose octasulfate (sos) complex.
2UUS · Heparin-binding growth factor 1: “Crystal structure of the rat FGF1-sucrose octasulfate (sos) complex.”. X-ray diffraction, 2 ligands (GU4, YYJ), 1 pocket (best druggability 0.68). MolNFT v1 #51009 on GenesisL1: 3D structure…
- PDB
- 2UUS
- Type
- protein
- Length
- 260 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heparin-binding growth factor 1
- UniProt
- P61149
- Ligands
- GU4, YYJ
- Pockets
- 1 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 10% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heparin-binding growth factor 1 | protein | 131 | 11% helix, 40% strand | P61149 |
| B | Heparin-binding growth factor 1 | protein | 129 | 9% helix, 39% strand | P61149 |
Ligands and binding sites
- GU4 · 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose · ligand · chains A
- YYJ · 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose · ligand · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 313 | 0.68 | 0.82 | 37 | empty |
Interfaces
1 interface between chains.
- A–B · 619 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 2UUS · Crystal structure of the rat FGF1-sucrose octasulfate (SOS) complex. · the same entry in another collection · chain B against B, TM-score 1.00
- P61149 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 1 (P61149) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61149
- Elsewhere: RCSB PDB 2UUS · PDBe 2UUS · UniProt P61149
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