MolNFT v1 · #50499 · protein
DHFR R67 complexed with NADP and dihydrofolate
2RK1 · Dihydrofolate reductase type 2: “DHFR R67 complexed with NADP and dihydrofolate”. X-ray diffraction, 2 ligands (DHF, NAP). MolNFT v1 #50499 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2RK1
- Type
- protein
- Length
- 58 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dihydrofolate reductase type 2
- EC
- 1.5.1.3
- UniProt
- P00383
- Ligands
- DHF, NAP
Structure
x-ray diffraction · 1 distinct chain · 5% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dihydrofolate reductase type 2 (EC 1.5.1.3) | protein | 58 | 5% helix, 45% strand | P00383 |
Ligands and binding sites
- DHF · Dihydrofolic acid · ligand
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
- MRD · (4R)-2-methylpentane-2,4-diol · additive · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00383
- Elsewhere: RCSB PDB 2RK1 · PDBe 2RK1 · UniProt P00383
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