UniProt P00383
Dihydrofolate reductase type 2 (P00383)
Dihydrofolate reductase type 2 (UniProt P00383), EC 1.5.1.3: 20 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00383
- Protein
- Dihydrofolate reductase type 2
- EC
- 1.5.1.3
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 3
Structures
21 records of P00383 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1VIE | Structure of dihydrofolate reductase | x-ray diffraction | A | — | — |
| 1VIE | Structure of dihydrofolate reductase | x-ray diffraction | A | — | — |
| 1VIF | Structure of dihydrofolate reductase | x-ray diffraction | A | — | — |
| 1VIF | Structure of dihydrofolate reductase | x-ray diffraction | A | — | — |
| 2GQV | High-resolution structure of a plasmid-encoded dihydrofolate reductase: pentagonal network of water… | x-ray diffraction | A | — | — |
| 2GQV | High-resolution structure of a plasmid-encoded dihydrofolate reductase: pentagonal network of water… | x-ray diffraction | A | — | — |
| 2P4T | Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor… | x-ray diffraction | A | — | — |
| 2P4T | Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor… | x-ray diffraction | A | — | — |
| 2RH2 | High Resolution DHFR R-67 | x-ray diffraction | A | — | — |
| 2RH2 | High resolution DHFR R-67 | x-ray diffraction | A | — | — |
| 2RK1 | DHFR R67 Complexed with NADP and dihydrofolate | x-ray diffraction | A | — | — |
| 2RK1 | DHFR R67 complexed with NADP and dihydrofolate | x-ray diffraction | A | — | — |
| 2RK2 | DHFR R-67 complexed with NADP | x-ray diffraction | A | — | — |
| 2RK2 | DHFR R-67 complexed with NADP | x-ray diffraction | A | — | — |
| 3SFM | Novel crystallization conditions for tandem variant R67 DHFR yields wild-type crystal structure | x-ray diffraction | A | — | — |
| 3SFM | Novel crystallization conditions for tandem variant R67 DHFR yields wild-type crystal structure | x-ray diffraction | A | — | — |
| 6NXZ | Crystal structure of trimethoprim-resistant type II dihydrofolate reductase in complex with a… | x-ray diffraction | A | D49, PO4 | — |
| 6NXZ | Crystal structure of trimethoprim-resistant type II dihydrofolate reductase in complex with a… | x-ray diffraction | A | D49, PO4 | — |
| 6NY0 | Crystal structure of trimethoprim-resistant type II dihydrofolate reductase in complex with a… | x-ray diffraction | A | LBA, PO4 | — |
| 6NY0 | Crystal structure of trimethoprim-resistant type II dihydrofolate reductase in complex with a… | x-ray diffraction | A | LBA, PO4 | — |
| P00383 | AlphaFold monomer V2.0 prediction for dihydrofolate reductase type 2 (P00383) | predicted | A | — | — |
Ligands
- PO4 · Phosphate ion · in 4 records
- D49 · 2-[4-[(2~{R})-4-[4-(6-carboxy-1~{H}-benzimidazol-2-yl) phenoxy]-2-oxidanyl-butoxy]phenyl]-1~{H}-benzimidazole-5-carboxylic acid · in 2 records
- LBA · 2-(4-{3-[4-(6-carboxy-1H-benzimidazol-2-yl)phenoxy]-2-hydroxypropoxy}phenyl)-1H-benzimidazole-5-carboxylic acid · in 2 records
Experiment against prediction
- 2RK1 chain A against the predicted model P00383: TM-score 0.99, RMSD 0.22 Å
- 2RK1 chain A against the predicted model P00383: TM-score 0.99, RMSD 0.22 Å
- 2RH2 chain A against the predicted model P00383: TM-score 0.99, RMSD 0.22 Å
- 2RH2 chain A against the predicted model P00383: TM-score 0.99, RMSD 0.22 Å
- 3SFM chain A against the predicted model P00383: TM-score 0.99, RMSD 0.23 Å
- 3SFM chain A against the predicted model P00383: TM-score 0.99, RMSD 0.23 Å
- 6NXZ chain A against the predicted model P00383: TM-score 0.99, RMSD 0.22 Å
- 6NXZ chain A against the predicted model P00383: TM-score 0.99, RMSD 0.22 Å
- 2RK2 chain A against the predicted model P00383: TM-score 0.99, RMSD 0.24 Å
- 2RK2 chain A against the predicted model P00383: TM-score 0.99, RMSD 0.24 Å
Elsewhere
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