MolNFT v1 · #50473 · protein
B-specific alpha-1,3-galactosyltransferase (gtb) +udp+ H-antigen disaccharide
2RJ8 · Glycoprotein-fucosylgalactoside alpha- galactosyltransferase: “B-specific alpha-1,3-galactosyltransferase (gtb) +udp+ H-antigen disaccharide”. X-ray diffraction, 3 ligands (BHE, UDP, MN), 2 pockets (best druggability 0.65). MolNFT…
- PDB
- 2RJ8
- Type
- protein
- Length
- 286 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycoprotein-fucosylgalactoside alpha- galactosyltransferase
- EC
- 2.4.1.37
- UniProt
- P16442
- Ligands
- BHE, UDP, MN
- Pockets
- 2 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glycoprotein-fucosylgalactoside alpha- galactosyltransferase (EC 2.4.1.37) | protein | 286 | 31% helix, 19% strand | P16442 |
Ligands and binding sites
- BHE · octyl 2-O-(6-deoxy-alpha-L-galactopyranosyl)-beta-D-galactopyranoside · ligand · chains A
- UDP · Uridine-5'-diphosphate · ligand · chains A
- MN · Manganese (II) ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 508 | 0.65 | 0.77 | 44 | BHE, UDP |
| 2 | 53 | 0.41 | 0.82 | 13 | empty |
Compared structures
- 2RJ8 · B-specific alpha-1,3-galactosyltransferase (GTB) +UDP+ H-antigen disaccharide · the same entry in another collection · chain A against A, TM-score 1.00
- P16442 · AlphaFold monomer V2.0 prediction for histo-blood group abo system transferase (P16442) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16442
- Elsewhere: RCSB PDB 2RJ8 · PDBe 2RJ8 · UniProt P16442
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