High resolution crystal structure of human B2-adrenergic G protein- coupled receptor.

Structure

x-ray diffraction · 1 distinct chain · 75% helix, 3% strand (DSSP).

Ligands and binding sites

• CLR · Cholesterol · ligand · 3 copies · chains A
• CAU · (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol · ligand · chains A
• ACM · Acetamide · ligand · chains A
• PLM · Palmitic acid · ligand · chains A
• GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A
• SO4 · Sulfate ion · ion · 6 copies · chains A
• BU1 · 1,4-butanediol · additive · 2 copies · chains A
• 12P · Dodecaethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 2 disulfide, 1 covalent, 1 lipid (disulfide, covalent ligand, palmitoylation).

Compared structures

• 2RH1 · High resolution crystal structure of human B2-adrenergic G protein-coupled receptor. · the same entry in another collection · chain A against A, TM-score 1.00
• P07550 · AlphaFold monomer V2.0 prediction for beta-2 adrenergic receptor (P07550) · a predicted model of the same protein · chain A against A, TM-score 0.66

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P07550
• Every structure of UniProt P00720
• Elsewhere: RCSB PDB 2RH1 · PDBe 2RH1 · UniProt P07550 · UniProt P00720