MolNFT v1 · #49509 · protein
Structure of C8A-macpf reveals mechanism of membrane attack in complement immune defense
2QQH · Complement component C8 alpha chain: “Structure of C8A-macpf reveals mechanism of membrane attack in complement immune defense”. X-ray diffraction, 2 ligands (NI, SO4), 3 pockets (best druggability 0.53). MolNFT v1 #49509 on…
- PDB
- 2QQH
- Type
- protein
- Length
- 304 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Complement component C8 alpha chain
- UniProt
- P07357
- Ligands
- NI, SO4
- Pockets
- 3 · best druggability 0.53
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Complement component C8 alpha chain | protein | 304 | 31% helix, 28% strand | P07357 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 61 | 0.53 | 0.87 | 22 | empty |
| 2 | 55 | 0.33 | 0.77 | 15 | empty |
| 3 | 50 | 0.33 | 0.78 | 16 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 2QQH · Structure of C8a-MACPF reveals mechanism of membrane attack in complement immune defense · the same entry in another collection · chain A against A, TM-score 1.00
- P07357 · AlphaFold monomer V2.0 prediction for complement component C8 alpha chain (P07357) · a predicted model of the same protein · chain A against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07357
- Elsewhere: RCSB PDB 2QQH · PDBe 2QQH · UniProt P07357
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