UniProt P07357
Complement component C8 alpha chain (P07357)
Complement component C8 alpha chain (UniProt P07357): 14 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P07357
- Protein
- Complement component C8 alpha chain
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 11 · 2 records with a druggable one
Structures
15 records of P07357 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2QOS | Crystal structure of complement protein C8 in complex with a peptide containing the C8 binding site… | x-ray diffraction | A | — | — |
| 2QOS | Crystal structure of complement protein C8 in complex with a peptide containing the C8 binding site… | x-ray diffraction | A | — | — |
| 2QQH | Structure of C8a-MACPF reveals mechanism of membrane attack in complement immune defense | x-ray diffraction | A | — | — |
| 2QQH | Structure of C8A-macpf reveals mechanism of membrane attack in complement immune defense | x-ray diffraction | A | — | — |
| 2RD7 | Human Complement Membrane Attack Proteins Share a Common Fold with Bacterial Cytolysins | x-ray diffraction | A | — | — |
| 2RD7 | Human complement membrane attack proteins share a common fold with bacterial cytolysins | x-ray diffraction | A | — | — |
| 3OJY | Crystal Structure of Human Complement Component C8 | x-ray diffraction | A | — | — |
| 3OJY | Crystal structure of human complement component C8 | x-ray diffraction | A | — | — |
| 6H03 | Open conformation of the membrane attack complex | electron microscopy | F | NAG | — |
| 6H04 | Closed conformation of the Membrane Attack Complex | electron microscopy | F | NAG | — |
| 6H04 | Closed conformation of the membrane attack complex | electron microscopy | F | NAG | — |
| 7NYC | Cryoem structure of 3C9-smac | electron microscopy | E | BMA, NAG, CA | — |
| 8B0G | 2C9, C5b9-CD59 structure | electron microscopy | E | NAG | 5 (best 0.87) |
| 8B0H | 2C9, C5b9-CD59 cryoEM structure | electron microscopy | E | — | 6 (best 0.85) |
| P07357 | AlphaFold monomer V2.0 prediction for complement component C8 alpha chain (P07357) | predicted | A | — | — |
Ligands
Experiment against prediction
- 3OJY chain A against the predicted model P07357: TM-score 0.98, RMSD 1.03 Å
- 3OJY chain A against the predicted model P07357: TM-score 0.98, RMSD 1.03 Å
- 2RD7 chain A against the predicted model P07357: TM-score 0.89, RMSD 2.13 Å
- 2RD7 chain A against the predicted model P07357: TM-score 0.89, RMSD 2.13 Å
- 2QQH chain A against the predicted model P07357: TM-score 0.86, RMSD 2.73 Å
- 2QQH chain A against the predicted model P07357: TM-score 0.86, RMSD 2.73 Å
- 7NYC chain E against the predicted model P07357: TM-score 0.76, RMSD 3.85 Å
- 8B0H chain E against the predicted model P07357: TM-score 0.75, RMSD 3.37 Å
- 8B0G chain E against the predicted model P07357: TM-score 0.75, RMSD 3.45 Å
- 2QOS chain A against the predicted model P07357: TM-score 0.73, RMSD 0.34 Å
Elsewhere
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