MolNFT v1 · #48054 · protein

Model for VP16 binding to PC4

2PHE · Transcriptional coactivator PC4: “Model for VP16 binding to PC4”. Solution nmr, 1 pocket (best druggability 0.43). MolNFT v1 #48054 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2PHE
Type: protein
Length: 158 residues
Chains: 3
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcriptional coactivator PC4; Alpha trans-inducing protein
UniProt: P53999, P06492
Pockets: 1 · best druggability 0.43

Structure

solution nmr · 2 distinct chains · 33% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Transcriptional coactivator PC4	protein	66	27% helix, 50% strand	P53999
C	Alpha trans-inducing protein	protein	26	46% helix, 0% strand	P06492

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	84	0.43	0.80	20	empty

Interfaces

3 interfaces between chains.

A–B · 1451 Å² buried · 10 hydrogen bonds · protein-protein
A–C · 1017 Å² buried · 27 hydrogen bonds · protein-protein
B–C · 298 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

2PHE · Model for VP16 binding to PC4 · the same entry in another collection · chain A against A, TM-score 1.00
P53999 · AlphaFold monomer V2.0 prediction for activated RNA polymerase II transcriptional… · a predicted model of the same protein · chain A against A, TM-score 0.84

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P53999
Every structure of UniProt P06492
Elsewhere: RCSB PDB 2PHE · PDBe 2PHE · UniProt P53999 · UniProt P06492

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