MolNFT v1 · #47743 · protein

Crystal structure of genomically encoded fosfomycin resistance protein, fosx, from listeria monocytogenes (hexagonal form)

2P7K · Glyoxalase family protein: “Crystal structure of genomically encoded fosfomycin resistance protein, fosx, from listeria monocytogenes…”. X-ray diffraction, 3 pockets (best druggability 0.83). MolNFT v1 #47743 on GenesisL1: 3D…

PDB: 2P7K
Type: protein
Length: 242 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glyoxalase family protein
UniProt: Q71YW5
Pockets: 3 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 20% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Glyoxalase family protein	protein	121	20% helix, 32% strand	Q71YW5

Ligands and binding sites

CIT · Citric acid · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	245	0.83	0.95	33	empty
2	148	0.51	0.79	24	CIT
3	163	0.50	0.78	23	CIT

Interfaces

1 interface between chains.

A–B · 1825 Å² buried · 26 hydrogen bonds · protein-protein

Compared structures

2P7K · Crystal structure of genomically encoded fosfomycin resistance protein, FosX, from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q71YW5
Elsewhere: RCSB PDB 2P7K · PDBe 2P7K · UniProt Q71YW5

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