MolNFT v1 · #47236 · protein
Solution structure and binding property of the domain-swapped dimer of ZO2PDZ2
2OSG · Tight junction protein zo-2: “Solution structure and binding property of the domain-swapped dimer of ZO2PDZ2”. Solution nmr, 1 pocket (best druggability 0.35). MolNFT v1 #47236 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 2OSG
- Type
- protein
- Length
- 166 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tight junction protein zo-2
- UniProt
- Q9UDY2
- Pockets
- 1 · best druggability 0.35
Structure
solution nmr · 1 distinct chain · 18% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Tight junction protein zo-2 | protein | 83 | 18% helix, 39% strand | Q9UDY2 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 60 | 0.35 | 0.78 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 2694 Ų buried · 49 hydrogen bonds · protein-protein
Compared structures
- 2OSG · Solution Structure and Binding Property of the Domain-swapped Dimer of ZO2PDZ2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UDY2 · AlphaFold monomer V2.0 prediction for tight junction protein zo-2 (Q9UDY2) · a predicted model of the same protein · chain A against A, TM-score 0.62
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UDY2
- Elsewhere: RCSB PDB 2OSG · PDBe 2OSG · UniProt Q9UDY2
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