Research workbench

Solution structure and binding property of the domain-swapped dimer of ZO2PDZ2

Analyse Solution structure and binding property of the domain-swapped dimer of ZO2PDZ2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2OSG
Type: protein
Length: 166 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tight junction protein zo-2
UniProt: Q9UDY2
Pockets: 1 · best druggability 0.35

Structure

solution nmr · 1 distinct chain · 18% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Tight junction protein zo-2	protein	83	18% helix, 39% strand	Q9UDY2

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	60	0.35	0.78	17	empty

Interfaces

1 interface between chains.

A–B · 2694 Å² buried · 49 hydrogen bonds · protein-protein

Compared structures

2OSG · Solution Structure and Binding Property of the Domain-swapped Dimer of ZO2PDZ2 · the same entry in another collection · chain A against A, TM-score 1.00
Q9UDY2 · AlphaFold monomer V2.0 prediction for tight junction protein zo-2 (Q9UDY2) · a predicted model of the same protein · chain A against A, TM-score 0.62

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UDY2
Elsewhere: RCSB PDB 2OSG · PDBe 2OSG · UniProt Q9UDY2

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.