MolNFT v1 · #47016 · protein
Crystal structure of E. COLI pseudouridine synthase rlue
2OLW · Ribosomal large subunit pseudouridine synthase E: “Crystal structure of E. COLI pseudouridine synthase rlue”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.60). MolNFT v1 #47016 on GenesisL1: 3D structure…
- PDB
- 2OLW
- Type
- protein
- Length
- 358 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribosomal large subunit pseudouridine synthase E
- EC
- 5.4.99.-
- UniProt
- P75966
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 16% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ribosomal large subunit pseudouridine synthase E (EC 5.4.99.-) | protein | 179 | 16% helix, 31% strand | P75966 |
| B | Ribosomal large subunit pseudouridine synthase E (EC 5.4.99.-) | protein | 179 | 16% helix, 33% strand | P75966 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · chains A
- ACY · Acetic acid · additive · 6 copies · chains A, B
- DTT · 2,3-dihydroxy-1,4-dithiobutane · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 207 | 0.60 | 0.82 | 37 | DTT |
| 2 | 211 | 0.60 | 0.81 | 32 | empty |
| 3 | 219 | 0.59 | 0.80 | 28 | empty |
| 4 | 101 | 0.53 | 0.83 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 725 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 2OLW · Crystal Structure of E. coli pseudouridine synthase RluE · the same entry in another collection · chain A against A, TM-score 1.00
- P75966 · AlphaFold monomer V2.0 prediction for ribosomal large subunit pseudouridine synthase E… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P75966
- Elsewhere: RCSB PDB 2OLW · PDBe 2OLW · UniProt P75966
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