MolNFT v1 · #46710 · protein
The crystal structure of the first PDZ domain of human nherf-2 (SLC9A3R2)
2OCS · NA(+)/H(+) exchange regulatory cofactor nhe-RF2: “The crystal structure of the first PDZ domain of human nherf-2 (SLC9A3R2)”. X-ray diffraction, 1 ligand (SCN), 1 pocket (best druggability 0.29). MolNFT v1 #46710 on GenesisL1: 3D…
- PDB
- 2OCS
- Type
- protein
- Length
- 85 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NA(+)/H(+) exchange regulatory cofactor nhe-RF2
- UniProt
- Q15599
- Ligands
- SCN
- Pockets
- 1 · best druggability 0.29
Structure
x-ray diffraction · 1 distinct chain · 15% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NA(+)/H(+) exchange regulatory cofactor nhe-RF2 | protein | 85 | 15% helix, 39% strand | Q15599 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 57 | 0.29 | 0.74 | 14 | empty |
Compared structures
- 2OCS · The crystal structure of the first PDZ domain of human NHERF-2 (SLC9A3R2) · the same entry in another collection · chain A against A, TM-score 1.00
- Q15599 · AlphaFold monomer V2.0 prediction for NA(+)/H(+) exchange regulatory cofactor nhe-RF2… · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15599
- Elsewhere: RCSB PDB 2OCS · PDBe 2OCS · UniProt Q15599
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.