MolNFT v1 · #46242 · protein
Crystal structure of the ankyrin repeat domain of TRPV1
2NYJ · Transient receptor potential cation channel subfamily V…: “Crystal structure of the ankyrin repeat domain of TRPV1”. X-ray diffraction, 1 ligand (ATP), 2 pockets (best druggability 0.39). MolNFT v1 #46242 on GenesisL1: 3D structure…
- PDB
- 2NYJ
- Type
- protein
- Length
- 244 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily V member 1
- UniProt
- O35433
- Ligands
- ATP
- Pockets
- 2 · best druggability 0.39
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transient receptor potential cation channel subfamily V member 1 | protein | 244 | 50% helix, 2% strand | O35433 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 87 | 0.39 | 0.77 | 17 | empty |
| 2 | 67 | 0.28 | 0.73 | 12 | empty |
Modifications
Observed in the structure: 3 modified (engineered).
Compared structures
- 2NYJ · Crystal structure of the ankyrin repeat domain of TRPV1 · the same entry in another collection · chain A against A, TM-score 1.00
- O35433 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O35433
- Elsewhere: RCSB PDB 2NYJ · PDBe 2NYJ · UniProt O35433
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