MolNFT v1 · #46088 · protein

PRONE8

2NTX · EMB|CAB41934.1: “PRONE8”. X-ray diffraction, 9 pockets (best druggability 0.64). MolNFT v1 #46088 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2NTX
Type: protein
Length: 601 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: EMB|CAB41934.1
UniProt: Q9LV40
Pockets: 9 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 72% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	EMB\|CAB41934.1	protein	314	70% helix, 4% strand	Q9LV40
B	EMB\|CAB41934.1	protein	287	73% helix, 3% strand	Q9LV40

Pockets

9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	343	0.64	0.80	47	empty
2	95	0.55	0.85	21	empty
3	213	0.53	0.77	26	empty
4	96	0.53	0.83	17	empty
5	123	0.48	0.80	25	empty

Interfaces

1 interface between chains.

A–B · 1353 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 28 modified (engineered).

Compared structures

2NTX · Prone8 · the same entry in another collection · chain A against A, TM-score 1.00
Q9LV40 · AlphaFold monomer V2.0 prediction for rho guanine nucleotide exchange factor 8 (Q9LV40) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9LV40
Elsewhere: RCSB PDB 2NTX · PDBe 2NTX · UniProt Q9LV40

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