MolNFT v1 · #384566 · protein
AlphaFold monomer V2.0 prediction for rho guanine nucleotide exchange factor 8 (Q9LV40)
Q9LV40: “AlphaFold monomer V2.0 prediction for rho guanine nucleotide exchange factor 8 (Q9LV40)”. 7 pockets (best druggability 0.71). MolNFT v1 #384566 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q9LV40
- Type
- protein
- Length
- 523 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x71112d4fF7ebb3b617963c05f052289e073082FD
- Molecule
- Rho guanine nucleotide exchange factor 8
- UniProt
- Q9LV40
- Pockets
- 7 · best druggability 0.71
Structure
1 distinct chain · 49% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rho guanine nucleotide exchange factor 8 | protein | 523 | 49% helix, 4% strand | Q9LV40 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 631 | 0.71 | 0.79 | 50 | empty |
| 2 | 117 | 0.49 | 0.80 | 18 | empty |
| 3 | 84 | 0.41 | 0.78 | 13 | empty |
| 4 | 60 | 0.38 | 0.79 | 12 | empty |
| 5 | 87 | 0.36 | 0.76 | 13 | empty |
Compared structures
- 2NTY · ROP4-GDP-PRONE8 · an experimental structure of the same protein · chain A against B, TM-score 0.63
- 2NTY · Rop4-GDP-PRONE8 · an experimental structure of the same protein · chain A against B, TM-score 0.63
- 2WBL · Three-dimensional structure of a binary rop-prone complex · an experimental structure of the same protein · chain A against B, TM-score 0.62
- 2WBL · Three-dimensional structure of a binary ROP-PRONE complex · an experimental structure of the same protein · chain A against B, TM-score 0.62
- 2NTX · Prone8 · an experimental structure of the same protein · chain A against A, TM-score 0.58
- 2NTX · PRONE8 · an experimental structure of the same protein · chain A against A, TM-score 0.58
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9LV40
- Elsewhere: UniProt Q9LV40 · AlphaFold DB Q9LV40
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