MolNFT v1 · #45959 · protein
Crystal structure of human methionine aminopeptidase type 1 in complex with 3-tert-butoxycarbonylaminopyridine-2-carboxylic acid thiazole-2- ylamide
2NQ6 · Methionine aminopeptidase 1: “Crystal structure of human methionine aminopeptidase type 1 in complex with…”. X-ray diffraction, 3 ligands (HM4, CO, CA), 2 pockets (best druggability 0.65). MolNFT v1 #45959 on GenesisL1: 3D…
- PDB
- 2NQ6
- Type
- protein
- Length
- 304 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Methionine aminopeptidase 1
- EC
- 3.4.11.18
- UniProt
- P53582
- Ligands
- HM4, CO, CA
- Pockets
- 2 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 27% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Methionine aminopeptidase 1 (EC 3.4.11.18) | protein | 304 | 27% helix, 22% strand | P53582 |
Ligands and binding sites
- HM4 · Tert-butyl {2-[(1,3-thiazol-2-ylamino)carbonyl]pyridin-3-yl}carbamate · ligand · chains A
- CO · Cobalt (II) ion · metal · 3 copies · chains A
- CA · Calcium ion · metal · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 50 | 0.65 | 0.95 | 21 | GOL |
| 2 | 301 | 0.60 | 0.78 | 37 | CO, HM4 |
Compared structures
- 2NQ6 · Crystal structure of human methionine aminopeptidase type 1 in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- P53582 · AlphaFold monomer V2.0 prediction for methionine aminopeptidase 1 (P53582) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53582
- Elsewhere: RCSB PDB 2NQ6 · PDBe 2NQ6 · UniProt P53582
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.