MolNFT v1 · #45377 · protein

Solution structure of human myosin VI ISOFORM3 (1050-1131)

2N12 · Unconventional myosin-VI: “Solution structure of human myosin VI ISOFORM3 (1050-1131)”. Solution nmr, 1 pocket (best druggability 0.28). MolNFT v1 #45377 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2N12
Type: protein
Length: 82 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Unconventional myosin-VI
UniProt: Q9UM54
Pockets: 1 · best druggability 0.28

Structure

solution nmr · 1 distinct chain · 60% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Unconventional myosin-VI	protein	82	60% helix, 0% strand	Q9UM54

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	60	0.28	0.74	13	empty

Compared structures

2N12 · Solution structure of human Myosin VI isoform3 (1050-1131) · the same entry in another collection · chain A against A, TM-score 1.00
Q9UM54 · AlphaFold monomer V2.0 prediction for unconventional myosin-VI (Q9UM54) · a predicted model of the same protein · chain A against A, TM-score 0.51

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UM54
Elsewhere: RCSB PDB 2N12 · PDBe 2N12 · UniProt Q9UM54

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