MolNFT v1 · #255621 · protein
AlphaFold monomer V2.0 prediction for unconventional myosin-VI (Q9UM54)
Q9UM54: “AlphaFold monomer V2.0 prediction for unconventional myosin-VI (Q9UM54)”. 12 pockets (best druggability 0.76). MolNFT v1 #255621 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q9UM54
- Type
- protein
- Length
- 1,294 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x1ED4a68B4011314730adE976b56Ad4cA21b54dcD
- Molecule
- Unconventional myosin-VI
- UniProt
- Q9UM54
- Pockets
- 12 · best druggability 0.76
Structure
1 distinct chain · 53% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Unconventional myosin-VI | protein | 1294 | 53% helix, 12% strand | Q9UM54 |
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 836 | 0.76 | 0.80 | 91 | empty |
| 2 | 456 | 0.70 | 0.81 | 49 | empty |
| 3 | 471 | 0.70 | 0.81 | 41 | empty |
| 4 | 136 | 0.64 | 0.86 | 37 | empty |
| 5 | 205 | 0.53 | 0.78 | 22 | empty |
Compared structures
- 8W41 · Cryo-EM structure of Myosin VI in the autoinhibited state · an experimental structure of the same protein · chain A against A, TM-score 0.61
- 6J56 · Crystal structure of myosin VI cbd in complex with TOM1 mbm · an experimental structure of the same protein · chain A against A, TM-score 0.08
- 6J56 · Crystal structure of Myosin VI CBD in complex with Tom1 MBM · an experimental structure of the same protein · chain A against A, TM-score 0.08
- 2N12 · Solution structure of human myosin VI ISOFORM3 (1050-1131) · an experimental structure of the same protein · chain A against A, TM-score 0.04
- 2N12 · Solution structure of human Myosin VI isoform3 (1050-1131) · an experimental structure of the same protein · chain A against A, TM-score 0.04
- 2N11 · Solution structure of human Myosin VI isoform3 (998-1071) · an experimental structure of the same protein · chain A against A, TM-score 0.04
- 2N11 · Solution structure of human myosin VI ISOFORM3 (998-1071) · an experimental structure of the same protein · chain A against A, TM-score 0.04
- 6E5N · Solution structure of human Myosin VI isoform 3 (1050-1131) in complex with Clathrin… · an experimental structure of the same protein · chain A against B, TM-score 0.04
- 6E5N · Solution structure of human myosin VI isoform 3 (1050-1131) in complex with clathrin… · an experimental structure of the same protein · chain A against B, TM-score 0.04
- 2N10 · Solution structure of MyUb (1080-1131) of human Myosin VI · an experimental structure of the same protein · chain A against A, TM-score 0.04
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UM54
- Elsewhere: UniProt Q9UM54 · AlphaFold DB Q9UM54
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