UniProt Q9UM54
Unconventional myosin-VI (Q9UM54)
Unconventional myosin-VI (UniProt Q9UM54): 13 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 34 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UM54
- Protein
- Unconventional myosin-VI
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 34 · 3 records with a druggable one
Structures
14 records of Q9UM54 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2N10 | Solution structure of MyUb (1080-1131) of human Myosin VI | solution nmr | A | — | — |
| 2N10 | Solution structure of myub (1080-1131) of human myosin VI | solution nmr | A | — | — |
| 2N11 | Solution structure of human Myosin VI isoform3 (998-1071) | solution nmr | A | — | — |
| 2N11 | Solution structure of human myosin VI ISOFORM3 (998-1071) | solution nmr | A | — | — |
| 2N12 | Solution structure of human Myosin VI isoform3 (1050-1131) | solution nmr | A | — | — |
| 2N12 | Solution structure of human myosin VI ISOFORM3 (1050-1131) | solution nmr | A | — | — |
| 2N13 | Complex structure of MyUb (1080-1122) of human Myosin VI with K63-diUb | solution nmr | A, D | — | — |
| 2N13 | Complex structure of myub (1080-1122) of human myosin VI with K63-diub | solution nmr | A, D | — | — |
| 6E5N | Solution structure of human Myosin VI isoform 3 (1050-1131) in complex with Clathrin light chain a… | solution nmr | B | — | — |
| 6E5N | Solution structure of human myosin VI isoform 3 (1050-1131) in complex with clathrin light chain a… | solution nmr | B | — | — |
| 6J56 | Crystal structure of Myosin VI CBD in complex with Tom1 MBM | x-ray diffraction | A, B | — | 4 (best 0.62) |
| 6J56 | Crystal structure of myosin VI cbd in complex with TOM1 mbm | x-ray diffraction | A, B | — | — |
| 8W41 | Cryo-EM structure of Myosin VI in the autoinhibited state | electron microscopy | A | ADP, MG, PO4 | 18 (best 0.80) |
| Q9UM54 | AlphaFold monomer V2.0 prediction for unconventional myosin-VI (Q9UM54) | predicted | A | — | 12 (best 0.76) |
Ligands
Experiment against prediction
- 6J56 chain B against the predicted model Q9UM54: TM-score 0.96, RMSD 0.86 Å
- 6J56 chain B against the predicted model Q9UM54: TM-score 0.96, RMSD 0.86 Å
- 6J56 chain A against the predicted model Q9UM54: TM-score 0.91, RMSD 1.45 Å
- 6J56 chain A against the predicted model Q9UM54: TM-score 0.91, RMSD 1.45 Å
- 2N13 chain A against the predicted model Q9UM54: TM-score 0.76, RMSD 1.71 Å
- 2N13 chain A against the predicted model Q9UM54: TM-score 0.76, RMSD 1.71 Å
- 8W41 chain A against the predicted model Q9UM54: TM-score 0.68, RMSD 3.72 Å
- 2N10 chain A against the predicted model Q9UM54: TM-score 0.59, RMSD 2.34 Å
- 2N10 chain A against the predicted model Q9UM54: TM-score 0.59, RMSD 2.34 Å
- 2N12 chain A against the predicted model Q9UM54: TM-score 0.51, RMSD 2.44 Å
Elsewhere
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