MolNFT v1 · #45323 · protein
NMR solution structure of the pro form of human matrilysin (prommp-7) in complex with zwitterionic membrane
2MZH: “NMR solution structure of the pro form of human matrilysin (prommp-7) in complex with zwitterionic membrane”. Solution nmr, 3 ligands (PX4, CA, ZN), 5 pockets (best druggability 0.64). MolNFT v1 #45323 on GenesisL1: 3D structure…
- PDB
- 2MZH
- Type
- protein
- Length
- 248 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Matrilysin
- EC
- 3.4.24.23
- UniProt
- P09237
- Ligands
- PX4, CA, ZN
- Pockets
- 5 · best druggability 0.64
Structure
solution nmr · 1 distinct chain · 30% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Matrilysin (EC 3.4.24.23) | protein | 248 | 30% helix, 10% strand | P09237 |
Ligands and binding sites
- PX4 · 1,2-dimyristoyl-sn-glycero-3-phosphocholine · ligand · 127 copies · chains A
- CA · Calcium ion · metal · 2 copies · chains A
- ZN · Zinc ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 161 | 0.64 | 0.86 | 34 | empty |
| 2 | 173 | 0.56 | 0.80 | 22 | empty |
| 3 | 100 | 0.54 | 0.84 | 23 | empty |
| 4 | 227 | 0.54 | 0.77 | 23 | empty |
| 5 | 57 | 0.32 | 0.76 | 12 | empty |
Compared structures
- 2MZH · NMR Solution Structure of the PRO Form of Human Matrilysin (proMMP-7) in Complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- P09237 · AlphaFold monomer V2.0 prediction for matrilysin (P09237) · a predicted model of the same protein · chain A against A, TM-score 0.74
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09237
- Elsewhere: RCSB PDB 2MZH · PDBe 2MZH · UniProt P09237
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.