MolNFT v1 · #45172 · protein
Solution structure of the F231L mutant ERCC1-xpf dimerization region
2MUT · DNA excision repair protein ercc-1: “Solution structure of the F231L mutant ERCC1-xpf dimerization region”. Solution nmr, 1 pocket (best druggability 0.33). MolNFT v1 #45172 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2MUT
- Type
- protein
- Length
- 180 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA excision repair protein ercc-1; DNA repair endonuclease xpf
- EC
- 3.1.-.-
- UniProt
- P07992, Q92889
- Pockets
- 1 · best druggability 0.33
Structure
solution nmr · 2 distinct chains · 59% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA excision repair protein ercc-1 | protein | 96 | 57% helix, 3% strand | P07992 |
| B | DNA repair endonuclease xpf (EC 3.1.-.-) | protein | 84 | 61% helix, 1% strand | Q92889 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 72 | 0.33 | 0.75 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1629 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 2MUT · Solution structure of the F231L mutant ERCC1-XPF dimerization region · the same entry in another collection · chain A against A, TM-score 1.00
- Q92889 · AlphaFold monomer V2.0 prediction for DNA repair endonuclease xpf (Q92889) · a predicted model of the same protein · chain B against A, TM-score 0.74
- P07992 · AlphaFold monomer V2.0 prediction for DNA excision repair protein ercc-1 (P07992) · a predicted model of the same protein · chain A against A, TM-score 0.63
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07992
- Every structure of UniProt Q92889
- Elsewhere: RCSB PDB 2MUT · PDBe 2MUT · UniProt P07992 · UniProt Q92889
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