UniProt Q92889
DNA repair endonuclease XPF (Q92889)
DNA repair endonuclease XPF (UniProt Q92889), EC 3.1.-.-: 14 experimental structures and 1 predicted model on GenesisL1, 40 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q92889
- Protein
- DNA repair endonuclease XPF
- EC
- 3.1.-.-
- Experimental structures
- 14
- Predicted models
- 1
- Pockets
- 40 · 3 records with a druggable one
Structures
15 records of Q92889 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1Z00 | Solution structure of the C-terminal domain of ERCC1 complexed with the C-terminal domain of XPF | solution nmr | B | — | — |
| 1Z00 | Solution structure of the C-terminal domain of ERCC1 complexed with the C-terminal domain of xpf | solution nmr | B | — | — |
| 2A1J | Crystal Structure of the Complex between the C-Terminal Domains of Human XPF and ERCC1 | x-ray diffraction | A | — | — |
| 2A1J | Crystal structure of the complex between the C-terminal domains of human xpf and ERCC1 | x-ray diffraction | A | — | — |
| 2AQ0 | Solution structure of the human homodimeric dna repair protein XPF | solution nmr | A, B | — | — |
| 2AQ0 | Solution structure of the human homodimeric DNA repair protein xpf | solution nmr | A, B | — | — |
| 2KN7 | Structure of the XPF-single strand DNA complex | solution nmr | A, D | — | — |
| 2KN7 | Structure of the xpf-single strand DNA complex | solution nmr | A, D | — | — |
| 2MUT | Solution structure of the F231L mutant ERCC1-XPF dimerization region | solution nmr | B | — | — |
| 2MUT | Solution structure of the F231L mutant ERCC1-xpf dimerization region | solution nmr | B | — | — |
| 6SXA | XPF-ERCC1 Cryo-EM Structure, Apo-form | electron microscopy | F | — | 12 (best 0.83) |
| 6SXA | Xpf-ERCC1 cryo-EM structure, apo-form | electron microscopy | F | — | — |
| 6SXB | XPF-ERCC1 Cryo-EM Structure, DNA-Bound form | electron microscopy | F | — | 15 (best 0.78) |
| 6SXB | Xpf-ERCC1 cryo-EM structure, DNA-bound form | electron microscopy | F | — | — |
| Q92889 | AlphaFold monomer V2.0 prediction for DNA repair endonuclease xpf (Q92889) | predicted | A | — | 13 (best 0.78) |
Experiment against prediction
- 2A1J chain A against the predicted model Q92889: TM-score 0.90, RMSD 1.57 Å
- 2A1J chain A against the predicted model Q92889: TM-score 0.90, RMSD 1.57 Å
- 2KN7 chain A against the predicted model Q92889: TM-score 0.87, RMSD 1.41 Å
- 2KN7 chain A against the predicted model Q92889: TM-score 0.87, RMSD 1.41 Å
- 6SXA chain F against the predicted model Q92889: TM-score 0.84, RMSD 2.99 Å
- 6SXA chain F against the predicted model Q92889: TM-score 0.84, RMSD 2.99 Å
- 6SXB chain F against the predicted model Q92889: TM-score 0.81, RMSD 3.83 Å
- 6SXB chain F against the predicted model Q92889: TM-score 0.81, RMSD 3.83 Å
- 2AQ0 chain A against the predicted model Q92889: TM-score 0.78, RMSD 1.97 Å
- 2AQ0 chain A against the predicted model Q92889: TM-score 0.78, RMSD 1.97 Å
Elsewhere
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