MolNFT v1 · #43222 · protein

Fat domain of focal adhesion kinase tethered to LD4 motif of paxillin via ggs linker

2L6H · Focal adhesion kinase 1, linker, paxillin: “Fat domain of focal adhesion kinase tethered to LD4 motif of paxillin via ggs linker”. Solution nmr, 1 pocket (best druggability 0.55). MolNFT v1 #43222 on GenesisL1: 3D structure, binding…

PDB: 2L6H
Type: protein
Length: 154 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Focal adhesion kinase 1, linker, paxillin
EC: 2.7.10.2
UniProt: Q00944, P49024
Pockets: 1 · best druggability 0.55

Structure

solution nmr · 1 distinct chain · 80% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Focal adhesion kinase 1, linker, paxillin (EC 2.7.10.2)	protein	154	80% helix, 0% strand	Q00944, P49024

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	75	0.55	0.86	17	empty

Compared structures

2L6H · Fat domain of focal adhesion kinase tethered to LD4 motif of paxillin via GGS linker · the same entry in another collection · chain A against A, TM-score 1.00
Q00944 · AlphaFold monomer V2.0 prediction for focal adhesion kinase 1 (Q00944) · a predicted model of the same protein · chain A against A, TM-score 0.68
P49024 · AlphaFold monomer V2.0 prediction for paxillin (P49024) · a predicted model of the same protein · chain A against A, TM-score 0.28

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q00944
Every structure of UniProt P49024
Elsewhere: RCSB PDB 2L6H · PDBe 2L6H · UniProt Q00944 · UniProt P49024

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.