UniProt Q00944
Focal adhesion kinase 1 (Q00944)
Focal adhesion kinase 1 (UniProt Q00944), EC 2.7.10.2: 65 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q00944
- Protein
- Focal adhesion kinase 1
- EC
- 2.7.10.2
- Experimental structures
- 65
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 21 · 2 records with a druggable one
Structures
66 records of Q00944 in the MolNFT archive: 65 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1KTM | Solution structure of fat domain of focal adhesion kinase | solution nmr | A | — | — |
| 1KTM | Solution structure of fat domain of focal adhesion kinase | solution nmr | A | — | — |
| 1PV3 | NMR Solution Structure of the Avian FAT-domain of Focal Adhesion Kinase | solution nmr | A | — | — |
| 1PV3 | NMR solution structure of the avian fat-domain of focal adhesion kinase | solution nmr | A | — | — |
| 1QVX | Solution structure of the fat domain of focal adhesion kinase | solution nmr | A | — | — |
| 1QVX | Solution structure of the fat domain of focal adhesion kinase | solution nmr | A | — | — |
| 2AEH | Focal adhesion kinase 1 | x-ray diffraction | A, B | — | — |
| 2AEH | Focal adhesion kinase 1 | x-ray diffraction | A, B | — | — |
| 2AL6 | FERM domain of Focal Adhesion Kinase | x-ray diffraction | A, B | — | — |
| 2AL6 | Ferm domain of focal adhesion kinase | x-ray diffraction | A, B | — | — |
| 2J0J | Crystal structure of a fragment of focal adhesion kinase containing the FERM and kinase domains. | x-ray diffraction | A | — | — |
| 2J0J | Crystal structure of a fragment of focal adhesion kinase containing the ferm and kinase domains. | x-ray diffraction | A | — | — |
| 2J0K | Crystal structure of a fragment of focal adhesion kinase containing the FERM and kinase domains. | x-ray diffraction | A, B | — | — |
| 2J0K | Crystal structure of a fragment of focal adhesion kinase containing the ferm and kinase domains. | x-ray diffraction | A, B | — | — |
| 2J0L | Crystal structure of a the active conformation of the kinase domain of focal adhesion kinase with a… | x-ray diffraction | A | — | — |
| 2J0L | Crystal structure of a the active conformation of the kinase domain of focal adhesion kinase with a… | x-ray diffraction | A | — | — |
| 2J0M | Crystal structure a two-chain complex between the FERM and kinase domains of focal adhesion kinase. | x-ray diffraction | A, B | — | — |
| 2J0M | Crystal structure a two-chain complex between the ferm and kinase domains of focal adhesion kinase. | x-ray diffraction | A, B | — | — |
| 2JKK | Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor | x-ray diffraction | A | — | — |
| 2JKK | Focal adhesion kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor | x-ray diffraction | A | — | — |
| 2JKM | Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor | x-ray diffraction | A | — | — |
| 2JKM | Focal adhesion kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor | x-ray diffraction | A | — | — |
| 2JKO | Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor | x-ray diffraction | A | — | — |
| 2JKO | Focal adhesion kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor | x-ray diffraction | A | — | — |
| 2JKQ | Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor | x-ray diffraction | A | — | — |
| 2JKQ | Focal adhesion kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor | x-ray diffraction | A | — | — |
| 2L6F | NMR Solution structure of FAT domain of FAK complexed with LD2 and LD4 motifs of PAXILLIN | solution nmr | A | — | — |
| 2L6F | NMR solution structure of fat domain of fak complexed with LD2 and LD4 motifs of paxillin | solution nmr | A | — | — |
| 2L6G | FAT-LD2 Double labeled construct with free LD4 peptide | solution nmr | A | — | — |
| 2L6G | Fat-LD2 double labeled construct with free LD4 peptide | solution nmr | A | — | — |
| 2L6H | Fat domain of focal adhesion kinase tethered to LD4 motif of paxillin via GGS linker | solution nmr | A | — | — |
| 2L6H | Fat domain of focal adhesion kinase tethered to LD4 motif of paxillin via ggs linker | solution nmr | A | — | — |
| 3ZDT | Crystal structure of basic patch mutant FAK FERM domain FAK31- 405 K216A, K218A, R221A, K222A | x-ray diffraction | A, B | — | — |
| 3ZDT | Crystal structure of basic patch mutant fak ferm domain FAK31-405 K216A, K218A, R221A, K222A | x-ray diffraction | A, B | — | — |
| 4BRX | Focal Adhesion Kinase catalytic domain in complex with a diarylamino- 1,3,5-triazine inhibitor | x-ray diffraction | A | — | — |
| 4BRX | Focal adhesion kinase catalytic domain in complex with a diarylamino- 1,3,5-triazine inhibitor | x-ray diffraction | A | — | — |
| 4C7T | Focal Adhesion Kinase catalytic domain in complex with a diarylamino- 1,3,5-triazine inhibitor | x-ray diffraction | A | — | — |
| 4C7T | Focal adhesion kinase catalytic domain in complex with a diarylamino- 1,3,5-triazine inhibitor | x-ray diffraction | A | — | — |
| 4CYE | Crystal structure of avian FAK FERM domain FAK31-405 at 3.2A | x-ray diffraction | A, B | — | — |
| 4CYE | Crystal structure of avian fak ferm domain FAK31-405 at 3.2A | x-ray diffraction | A, B | — | — |
| 4D4R | Focal Adhesion Kinase catalytic domain | x-ray diffraction | A, B | — | — |
| 4D4R | Focal adhesion kinase catalytic domain | x-ray diffraction | A, B | — | — |
| 4D4S | Focal Adhesion Kinase catalytic domain | x-ray diffraction | A, B | — | — |
| 4D4S | Focal adhesion kinase catalytic domain | x-ray diffraction | A, B | — | — |
| 4D4V | Focal Adhesion Kinase catalytic domain | x-ray diffraction | A, B | — | — |
| 4D4V | Focal adhesion kinase catalytic domain | x-ray diffraction | A, B | — | — |
| 4D4Y | Focal Adhesion Kinase catalytic domain | x-ray diffraction | A, B | — | — |
| 4D4Y | Focal adhesion kinase catalytic domain | x-ray diffraction | A, B | — | — |
| 4D55 | Focal Adhesion Kinase catalytic domain | x-ray diffraction | A | — | — |
| 4D55 | Focal adhesion kinase catalytic domain | x-ray diffraction | A | — | — |
| 4D58 | Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor | x-ray diffraction | A, B | — | — |
| 4D58 | Focal adhesion kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor | x-ray diffraction | A, B | — | — |
| 4D5H | Focal Adhesion Kinase catalytic domain | x-ray diffraction | A, B | — | — |
| 4D5H | Focal adhesion kinase catalytic domain | x-ray diffraction | A, B | — | — |
| 4D5K | Focal Adhesion Kinase catalytic domain | x-ray diffraction | A, B | — | — |
| 4D5K | Focal adhesion kinase catalytic domain | x-ray diffraction | A, B | — | — |
| 6CB0 | Crystal structure of the fak ferm domain | x-ray diffraction | A, B | — | — |
| 6GCR | Focal Adhesion Kinase catalytic domain in complex with irreversible inhibitor | x-ray diffraction | A | EUW | 1 (best 0.62) |
| 6GCR | Focal adhesion kinase catalytic domain in complex with irreversible inhibitor | x-ray diffraction | A | EUW | — |
| 6GCW | Focal Adhesion Kinase catalytic domain in complex with irreversible inhibitor | x-ray diffraction | A, B | EUQ, SO4 | — |
6 records more on the page itself.
Ligands
- EUW · 2-[[2-[[4-[[[3,4-bis(oxidanylidene)-2-[2-(propanoylamino)ethylamino]cyclobuten-1-yl]amino]methyl]phenyl]amino]-5-chloranyl-pyrimidin-4-yl]amino]-~{N}-methyl-benzamide · in 3 records
- SO4 · Sulfate ion · in 3 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
- EUQ · 2-[[5-chloranyl-2-[[4-[[[1-[2-(propanoylamino)ethyl]-1, 2,3-triazol-4-yl]methylamino]methyl]phenyl]amino]pyrimidin-4-yl]amino]-~{N}-methyl-benzamide · in 2 records
- MG · Magnesium ion · in 2 records
Experiment against prediction
- 4CYE chain B against the predicted model Q00944: TM-score 0.99, RMSD 0.71 Å
- 4CYE chain B against the predicted model Q00944: TM-score 0.99, RMSD 0.71 Å
- 2J0M chain B against the predicted model Q00944: TM-score 0.99, RMSD 0.68 Å
- 2J0M chain B against the predicted model Q00944: TM-score 0.99, RMSD 0.68 Å
- 3ZDT chain A against the predicted model Q00944: TM-score 0.99, RMSD 0.79 Å
- 3ZDT chain A against the predicted model Q00944: TM-score 0.99, RMSD 0.79 Å
- 4CYE chain A against the predicted model Q00944: TM-score 0.99, RMSD 0.87 Å
- 4CYE chain A against the predicted model Q00944: TM-score 0.99, RMSD 0.87 Å
- 2AEH chain A against the predicted model Q00944: TM-score 0.99, RMSD 0.90 Å
- 2AEH chain A against the predicted model Q00944: TM-score 0.99, RMSD 0.90 Å
Elsewhere
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