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Ligand · 4ST

4ST · 1,2,3,4-tetrahydrogen-staurosporine

4ST, 1,2,3,4-tetrahydrogen-staurosporine (C28 H30 N4 O3, 470.6 g/mol), in the MolNFT structures on GenesisL1: bound in 10 records (5 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…

Component
4ST
Formula
C28 H30 N4 O3
Class
ligand
Structures
10
PDB entries
5

Binding sites

4ST in 10 structures; the first of them:

  • 1YVJ · Crystal structure of the Jak3 kinase domain in complex with a staurosporine analogue · 4ST A2000 · binds LEU828, GLY829, LYS830, VAL836, ALA853, LYS855, VAL884, MET902 and 11 more
  • 2HZ4 · Abl kinase domain unligated and in complex with tetrahydrostaurosporine · 4ST A501 · binds TRP235, TRP261, TYR264, LEU266, LYS294, GLN300, LEU301, LEU302 and 5 more
  • 2J0J · Crystal structure of a fragment of focal adhesion kinase containing the FERM and kinase… · 4ST A1687 · binds ILE428, GLY429, GLU430, VAL436, ALA452, LYS454, GLU471, VAL484 and 10 more
  • 2J0K · Crystal structure of a fragment of focal adhesion kinase containing the FERM and kinase… · 4ST A1687 · binds ILE428, GLY429, GLU430, VAL436, ALA452, LYS454, GLU471, VAL484 and 10 more
  • 2J0M · Crystal structure a two-chain complex between the FERM and kinase domains of focal… · 4ST B1687 · binds ILE428, GLY429, GLU430, GLY431, VAL436, ALA452, LYS454, VAL484 and 10 more
  • 1YVJ · Crystal structure of the JAK3 kinase domain in complex with a staurosporine analogue · 4ST A2000 · binds LEU828, GLY829, LYS830, VAL836, ALA853, LYS855, VAL884, MET902 and 11 more
  • 2HZ4 · Abl kinase domain unligated and in complex with tetrahydrostaurosporine · 4ST A501 · binds TRP235, TRP261, TYR264, LEU266, LYS294, GLN300, LEU301, LEU302 and 5 more
  • 2J0J · Crystal structure of a fragment of focal adhesion kinase containing the ferm and kinase… · 4ST A1687 · binds ILE428, GLY429, GLU430, VAL436, ALA452, LYS454, GLU471, VAL484 and 10 more
  • 2J0K · Crystal structure of a fragment of focal adhesion kinase containing the ferm and kinase… · 4ST A1687 · binds ILE428, GLY429, GLU430, VAL436, ALA452, LYS454, GLU471, VAL484 and 10 more
  • 2J0M · Crystal structure a two-chain complex between the ferm and kinase domains of focal… · 4ST B1687 · binds ILE428, GLY429, GLU430, GLY431, VAL436, ALA452, LYS454, VAL484 and 10 more

Residues it binds most

GLU 14, LEU 16, GLY 12, VAL 12, LYS 16, ALA 12, ARG 12, ASN 12, ASP 12, MET 12 (residue and the binding sites it lines).

Found with

  • DTV · (2S,3S)-1,4-dimercaptobutane-2,3-diol

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