MolNFT v1 · #40703 · protein
Crystal structure a two-chain complex between the ferm and kinase domains of focal adhesion kinase.
2J0M · Focal adhesion kinase 1: “Crystal structure a two-chain complex between the ferm and kinase domains of focal adhesion kinase.”. X-ray diffraction, 1 ligand (4ST), 9 pockets (best druggability 0.63). MolNFT v1 #40703 on GenesisL1: 3D…
- PDB
- 2J0M
- Type
- protein
- Length
- 586 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Focal adhesion kinase 1
- EC
- 2.7.10.2
- UniProt
- Q00944
- Ligands
- 4ST
- Pockets
- 9 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Focal adhesion kinase 1 (EC 2.7.10.2) | protein | 329 | 37% helix, 20% strand | Q00944 |
| B | Focal adhesion kinase 1 (EC 2.7.10.2) | protein | 257 | 42% helix, 18% strand | Q00944 |
Ligands and binding sites
- 4ST · 1,2,3,4-tetrahydrogen-staurosporine · ligand · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 362 | 0.63 | 0.78 | 35 | 4ST |
| 2 | 335 | 0.61 | 0.78 | 35 | empty |
| 3 | 233 | 0.60 | 0.80 | 33 | empty |
| 4 | 94 | 0.47 | 0.80 | 17 | empty |
| 5 | 54 | 0.46 | 0.85 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 721 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 2J0M · Crystal structure a two-chain complex between the FERM and kinase domains of focal… · the same entry in another collection · chain A against A, TM-score 1.00
- Q00944 · AlphaFold monomer V2.0 prediction for focal adhesion kinase 1 (Q00944) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00944
- Elsewhere: RCSB PDB 2J0M · PDBe 2J0M · UniProt Q00944
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