MolNFT v1 · #43028 · protein

Solution structure of the complex of ubiquitin and the vhs domain of STAM2

2L0T: “Solution structure of the complex of ubiquitin and the vhs domain of STAM2”. Solution nmr, 1 pocket (best druggability 0.40). MolNFT v1 #43028 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2L0T
Type: protein
Length: 239 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin; Signal transducing adapter molecule 2
UniProt: P62988, O75886
Pockets: 1 · best druggability 0.40

Structure

solution nmr · 2 distinct chains · 46% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ubiquitin	protein	76	16% helix, 33% strand	P62988
B	Signal transducing adapter molecule 2	protein	163	61% helix, 0% strand	O75886

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	152	0.40	0.73	20	empty

Interfaces

1 interface between chains.

A–B · 501 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

2L0T · Solution structure of the complex of ubiquitin and the VHS domain of Stam2 · the same entry in another collection · chain A against A, TM-score 1.00
O75886 · AlphaFold monomer V2.0 prediction for signal transducing adapter molecule 2 (O75886) · a predicted model of the same protein · chain B against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62988
Every structure of UniProt O75886
Elsewhere: RCSB PDB 2L0T · PDBe 2L0T · UniProt P62988 · UniProt O75886

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