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Solution structure of the complex of ubiquitin and the vhs domain of STAM2

Analyse Solution structure of the complex of ubiquitin and the vhs domain of STAM2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2L0T
Type: protein
Length: 239 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin; Signal transducing adapter molecule 2
UniProt: P62988, O75886
Pockets: 1 · best druggability 0.40

Structure

solution nmr · 2 distinct chains · 46% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ubiquitin	protein	76	16% helix, 33% strand	P62988
B	Signal transducing adapter molecule 2	protein	163	61% helix, 0% strand	O75886

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	152	0.40	0.73	20	empty

Interfaces

1 interface between chains.

A–B · 501 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

2L0T · Solution structure of the complex of ubiquitin and the VHS domain of Stam2 · the same entry in another collection · chain A against A, TM-score 1.00
O75886 · AlphaFold monomer V2.0 prediction for signal transducing adapter molecule 2 (O75886) · a predicted model of the same protein · chain B against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62988
Every structure of UniProt O75886
Elsewhere: RCSB PDB 2L0T · PDBe 2L0T · UniProt P62988 · UniProt O75886

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