MolNFT v1 · #42715 · protein
Solution structure of EIF3B-rrm bound to EIF3J peptide
2KRB · Eukaryotic translation initiation factor 3 subunit B: “Solution structure of EIF3B-rrm bound to EIF3J peptide”. Solution nmr, 1 pocket (best druggability 0.53). MolNFT v1 #42715 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 2KRB
- Type
- protein
- Length
- 92 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 3 subunit B; Eukaryotic translation initiation…
- UniProt
- P55884, O75822
- Pockets
- 1 · best druggability 0.53
Structure
solution nmr · 2 distinct chains · 23% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 3 subunit B | protein | 81 | 26% helix, 22% strand | P55884 |
| B | Eukaryotic translation initiation factor 3 subunit J | protein | 11 | 0% helix, 0% strand | O75822 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 146 | 0.53 | 0.80 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 598 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 2KRB · Solution structure of EIF3B-RRM bound to EIF3J peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P55884 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit… · a predicted model of the same protein · chain A against A, TM-score 0.80
- O75822 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit… · a predicted model of the same protein · chain B against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55884
- Every structure of UniProt O75822
- Elsewhere: RCSB PDB 2KRB · PDBe 2KRB · UniProt P55884 · UniProt O75822
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