MolNFT v1 · #42340 · protein
Structure of the N-terminal domain of human cardiac troponin C bound to calcium ion and to the inhibitor W7
2KFX · Troponin C, slow skeletal and cardiac muscles: “Structure of the N-terminal domain of human cardiac troponin C bound to calcium ion and to the inhibitor W7”. Solution nmr, 2 ligands (WW7, CA), 2 pockets (best druggability 0.51).…
- PDB
- 2KFX
- Type
- protein
- Length
- 89 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Troponin C, slow skeletal and cardiac muscles
- UniProt
- P63316
- Ligands
- WW7, CA
- Pockets
- 2 · best druggability 0.51
Structure
solution nmr · 1 distinct chain · 60% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| T | Troponin C, slow skeletal and cardiac muscles | protein | 89 | 60% helix, 0% strand | P63316 |
Ligands and binding sites
- WW7 · N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide · ligand · chains T
- CA · Calcium ion · metal · chains T
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 144 | 0.51 | 0.78 | 19 | WW7 |
| 2 | 55 | 0.39 | 0.80 | 14 | empty |
Compared structures
- 2KFX · Structure of the N-terminal domain of human cardiac troponin C bound to calcium ion and… · the same entry in another collection · chain T against T, TM-score 1.00
- P63316 · AlphaFold monomer V2.0 prediction for troponin C, slow skeletal and cardiac muscles… · a predicted model of the same protein · chain T against A, TM-score 0.75
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63316
- Elsewhere: RCSB PDB 2KFX · PDBe 2KFX · UniProt P63316
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