MolNFT v1 · #41200 · protein
Structure of the human EIF4E homologous protein, 4EHP without ligand bound
2JGC · Eukaryotic translation initiation factor 4E type 2: “Structure of the human EIF4E homologous protein, 4EHP without ligand bound”. X-ray diffraction, 1 pocket (best druggability 0.53). MolNFT v1 #41200 on GenesisL1: 3D structure…
- PDB
- 2JGC
- Type
- protein
- Length
- 188 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 4E type 2; Eukaryotic translation initiation…
- UniProt
- O60573, Q13541
- Pockets
- 1 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 25% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 4E type 2 | protein | 172 | 22% helix, 33% strand | O60573 |
| B | Eukaryotic translation initiation factor 4E-binding protein 1 | protein | 16 | 56% helix, 0% strand | Q13541 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 269 | 0.53 | 0.75 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 764 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 2JGC · Structure of the human eIF4E homologous protein, 4EHP without ligand bound · the same entry in another collection · chain A against A, TM-score 1.00
- O60573 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E type 2… · a predicted model of the same protein · chain A against A, TM-score 0.96
- Q13541 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E-binding… · a predicted model of the same protein · chain B against A, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60573
- Every structure of UniProt Q13541
- Elsewhere: RCSB PDB 2JGC · PDBe 2JGC · UniProt O60573 · UniProt Q13541
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